Dolo 650 Tablet
Paracetamol (650mg)
A paracetamol brand used for the temporary relief of fever and mild to moderate pain.
- Manufacturer
- Micro Labs Ltd
- Pack
- strip of 15 tablets
- Dosage form
- tablet
- Indicative MRP
- ₹33.90
Sold by our partner store.
Dolo 650 Tablet contains Paracetamol (acetaminophen), one of the most widely used medicines for reducing fever and relieving mild to moderate pain. It is generally well tolerated when taken at the recommended dose and is gentler on the stomach than most other common pain relievers.
At a glance
Paracetamol 650mg Tablet (650mg tablet)
Turns down fever and dulls pain by raising the body's pain threshold and acting on the brain's heat-regulating centre.
Fever, body pain, headache, period pain, toothache, and the aches of cold and flu.
Uses of Dolo 650 Tablet
- Fever
- Headache and migraine
- Body ache and muscle pain
- Toothache and dental pain
- Aches associated with cold and flu
- Period (menstrual) pain
Benefits of Dolo 650 Tablet
Pain relief: Dolo 650 Tablet blocks the chemical messengers in the brain that signal pain, easing headaches, body aches and other everyday pain without irritating the stomach lining the way NSAIDs can.
Fever reduction: It acts on the heat-regulating centre in the brain (hypothalamus) to bring a raised body temperature back toward normal, usually within 30 to 60 minutes of a dose.
Side effects of Dolo 650 Tablet
Most people experience no side effects at the recommended dose. Uncommon effects include nausea and skin rash.
- Seek medical help immediately for signs of an allergic reaction (swelling of the face or throat, difficulty breathing) or a severe skin reaction (blistering, peeling).
- Taking more than the recommended amount can cause serious liver damage, even before any symptoms appear.
Side effects in detail
| Side effect | How common | How severe | What to do |
|---|---|---|---|
| Nausea, stomach discomfort | Uncommon | Mild | Take with food; sip fluids. Settles on its own. |
| Skin rash | Uncommon | Mild | Stop the medicine if it worsens; consult a doctor. |
| Liver injury (with overdose) | Rare | Severe | Emergency care — see the overdose protocol below. |
| Low platelet count | Rare | Moderate | Report unusual bruising or bleeding to a doctor. |
| Allergic reaction / angioedema | Rare | Life-threatening | Stop immediately and seek emergency care. |
How to manage side effects
Nausea, stomach discomfort
- Sip water, ginger tea or clear soups slowly
- Eat small, bland meals — crackers, toast, rice
- Avoid strong smells and spicy food
- Rest; avoid sudden movements
Skin rash
- Stop the medicine and note the timing
- Avoid scratching; loose cotton clothing helps
- Seek urgent care for blistering or peeling
- Tell every future caregiver about the reaction
Liver injury (with overdose)
- Go to hospital immediately
- Do not wait for symptoms — liver injury can be silent for 24 hours
Low platelet count
- Report unusual bruising or bleeding
- Do not stop the medicine on your own — ask a doctor first
Allergic reaction / angioedema
- Stop the medicine immediately
- Seek emergency care for swelling, breathlessness or rash
- Avoid paracetamol in every future product
How to use Dolo 650 Tablet
- Swallow the tablet whole with a glass of water; do not chew or crush it.
- It can be taken with or without food, but taking it after food reduces the chance of stomach upset.
- Leave a gap of at least 4 to 6 hours between doses.
- Do not take more than 4 doses (a maximum of 4 g of Paracetamol in total) in 24 hours.
Special population advice
Kidney impairment
- eGFR 10–50: extend the gap between doses to ~6 hours
- eGFR <10: only under medical supervision
Liver impairment
- Avoid in severe impairment or active liver disease
- Chronic liver disease or regular alcohol use: cap at 2 g/day, ask a doctor
Children
- Not for children under 10–12 years
- Younger children: paediatric form, 10–15 mg/kg per dose
Elderly
- Lowest effective dose, shortest duration
- Review liver function and other medicines regularly
How Dolo 650 Tablet works
Dolo 650 Tablet works mainly in the brain and spinal cord. It reduces the production of prostaglandins — chemical messengers that cause pain and raise body temperature — by inhibiting cyclo-oxygenase (COX) enzymes centrally. This relieves pain and resets the body temperature set-point during fever.
What if you miss or exceed a dose?
If you miss a dose
Dolo 650 Tablet is usually taken only when needed. If you are on a schedule and miss a dose, take it as soon as you remember — unless it is almost time for the next dose. Never take a double dose to make up for a missed one.
In case of overdose
An overdose of Dolo 650 Tablet can cause serious, sometimes fatal, liver damage. Symptoms may not appear for 24 hours or more, so seek emergency medical care immediately after a suspected overdose even if you feel well.
Most effective within 8–10 hours of ingestion; still beneficial later. Given in hospital only.
- Activated charcoal
- May be considered within 1 hour of ingestion, on medical advice.
- Blood level
- 4-hour post-ingestion paracetamol level where available (Rumack–Matthew nomogram).
- Monitoring
- LFTs, INR, serum creatinine and glucose at baseline, then at least every 24 hours.
- Do not wait
- Go to hospital even with no symptoms — liver injury can be silent for a day.
When to avoid Dolo 650 Tablet
- Known allergy to paracetamol or any ingredient of the tablet
Stop and seek emergency care for rash, swelling or breathlessness.
- Severe hepatic impairment or active liver disease
Unless a doctor specifically advises it.
- Chronic alcohol use, malnutrition or low body weight
Higher liver-injury risk.
- Sepsis or severe infection
- Severe kidney disease
- Already taking warfarin, antiepileptics or other paracetamol-containing products
Substitutes
Same composition as Dolo 650 Tablet. Prices are indicative MRP. Never switch medicines on your own — confirm any substitute with your doctor or pharmacist.
See all substitutes →Safety advice
Avoid alcohol; the combination increases the risk of liver damage.
Generally considered the preferred pain reliever in pregnancy, but use only at the lowest effective dose after consulting a doctor.
Considered safe during breastfeeding; only small amounts pass into breast milk.
Does not usually affect the ability to drive or use machines.
Use with caution in significant kidney disease; a longer gap between doses may be needed.
Use with caution in liver disease and avoid in severe liver impairment; ask a doctor first.
Do not take if allergic to paracetamol or any excipient. Rash, swelling or breathlessness means stop and seek emergency care.
Not recommended below 10–12 years. Use weight-based paediatric preparations instead.
Lowest effective dose for the shortest time; review liver function and co-medicines periodically.
Quick tips
- Many cold, flu and combination pain medicines already contain Paracetamol — check labels so you do not double up.
- Avoid alcohol while taking Dolo 650 Tablet; the combination increases the risk of liver damage.
- See a doctor if fever lasts more than 3 days or pain lasts more than 5 days despite treatment.
- For children, use a paediatric preparation dosed by body weight, not adult tablets.
Interactions with other medicines
Warfarin and other blood thinners
MajorChanges the medicine’s effect
What can happen: Regular daily paracetamol can raise bleeding risk (unusual bruising, blood in urine or stools).
What to do: Occasional doses are usually acceptable; the doctor monitors INR. Report any bleeding signs.
Other paracetamol-containing products
MajorChanges the medicine’s effect
What can happen: Cumulative overdose and liver damage.
What to do: Check every label; count paracetamol from all sources against the 4 g/day ceiling.
Carbamazepine, phenytoin, rifampicin
ModerateChanges how the medicine is processed
What can happen: Increased risk of liver injury with regular dosing.
What to do: Keep courses short; the doctor may monitor liver function.
SSRI antidepressants (with blood thinners)
ModerateChanges the medicine’s effect
What can happen: Added bleeding risk when combined with anticoagulants.
What to do: Tell your doctor about every medicine; monitor for bruising.
Cholestyramine
MinorChanges how the medicine is processed
What can happen: Reduced paracetamol absorption and effect.
What to do: Separate the doses by at least 1 hour.
Pharmacokinetics
- Absorption
- Rapid; peak in 0.5–1 hour
- Bioavailability
- ~63–89%
- Protein binding
- 10–25%
- Volume of distribution
- ~0.9 L/kg
- Half-life
- 2–3 hours
- Metabolism
- Liver glucuronidation and sulfation; minor CYP2E1 to NAPQI
- Excretion
- Renal (metabolites)
- Onset / duration
- Onset 30–60 min; duration 4–6 hours
Fact box
- Chemical class
- Para-aminophenol derivative
- Habit forming
- No
- Therapeutic class
- Analgesic and antipyretic
- Action class
- Central COX inhibitor
- Storage
- Store below 25°C in a dry place, protected from light. Keep out of reach of children.
- ATC code
- N02BE01
- Pregnancy category
- B
More information
Why doctors recommend paracetamol first for fever and pain
Paracetamol is usually the first medicine doctors reach for in simple fever and everyday pain because it works well, has a wide safety margin at correct doses, and — unlike NSAIDs — barely irritates the stomach, doesn't affect platelets, and is safe in pregnancy at the lowest effective dose. It also combines safely with many other medicines when a doctor supervises, which matters for people already on treatment.
Its fast onset (30–60 minutes) and 4–6 hour duration make it predictable: people know when it should work and when they can safely re-dose. Availability and low cost complete the picture — during flu season and dengue outbreaks it remains the most accessible option across India.
Lifestyle and diet tips while taking Dolo 650 Tablet
Take the tablet with food or milk if you have a sensitive stomach, and drink a full glass of water. Avoid alcohol entirely — the combination multiplies liver risk. Keep meals light: very fatty food can delay absorption and slow relief.
Stay hydrated during fever, rest while symptoms last, and keep a note of every dose you take — including combination cold remedies — so you never cross the 4 g daily ceiling from all sources combined. If you need it beyond 3 days (fever) or 5 days (pain), see a doctor rather than continuing.
Paracetamol vs ibuprofen, aspirin and combination painkillers
vs Ibuprofen (an NSAID): ibuprofen adds anti-inflammatory action, so it often wins when pain involves swelling — sprains, dental swelling, arthritis flares. But it can irritate the stomach, affect kidneys and raise blood pressure. For plain fever and headache, paracetamol is usually preferred and is the safer choice in pregnancy and in people with ulcers or kidney issues.
vs Aspirin: aspirin relieves pain, fever and inflammation but carries higher stomach-bleeding risk and is avoided in children with viral fever (Reye's syndrome). For routine fever care, paracetamol has displaced it.
vs Combination tablets (e.g. aceclofenac + paracetamol): combinations address fever plus inflammation together and can give broader relief — that is why Zerodol-P-type prescriptions exist — but they also stack side-effect risk (stomach, kidney). They belong under prescription; do not self-combine.
Bottom line: for simple fever and mild-to-moderate body pain, start with paracetamol; move to NSAIDs or combinations only when inflammation is clearly part of the problem, ideally with a doctor's input.
References
- Grosser T, Smyth E, FitzGerald GA. Anti-inflammatory, antipyretic and analgesic agents; pharmacotherapy of gout. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 12th ed. New York: McGraw Hill; 2011. p. 693.
- Tripathi KD. NSAIDs and antipyretic-analgesics. Essentials of Medical Pharmacology. 7th ed. 2013. p. 206.
- Freo U, Ruocco C, Valerio A, Scagnol I, Nisoli E. Paracetamol: a review of guideline recommendations. NIH National Library of Medicine. August 2021.View sourceAccessed 19 Mar 2026
- Ohashi N, Kohno T. Analgesic effect of acetaminophen: a review of known and novel mechanisms of action. Frontiers in Pharmacology. November 2020.View sourceAccessed 19 Mar 2026
- Zentiva Pharma UK Limited. Paracetamol 500 mg Tablets — Patient Information Leaflet. Electronic Medicines Compendium (EMC). Revised May 2022.View sourceAccessed 19 Mar 2026
- GlaxoSmithKline Asia Pvt Ltd. Crocin 650 mg (Paracetamol) product information.View sourceAccessed 19 Mar 2026
Frequently asked questions
How quickly does Dolo 650 Tablet work?
It usually starts relieving pain and fever within 30 to 60 minutes, and the effect lasts about 4 to 6 hours.
Can I take Dolo 650 Tablet with ibuprofen?
They can be combined for short periods in adults if a doctor advises it, since they work in different ways — but do not combine them on your own for children.
What is the maximum safe dose in a day?
Adults should not exceed 4 g of Paracetamol in 24 hours from all sources, including combination cold and flu remedies.
Is Dolo 650 Tablet safe for long-term daily use?
It is intended for short-term relief. If you need it daily for more than a few days, see a doctor to find and treat the underlying cause.
Is Dolo 650 Tablet an antibiotic?
No. It only relieves pain and fever; it does not treat the infection causing them.
Active ingredients
Analgesic / Antipyretic
Paracetamol 650mg Tablet
Dolo 650 Tablet contains Paracetamol (acetaminophen), one of the most widely used medicines for reducing fever and relieving mild to moderate pain. It is generally well tolerated when taken at the…
Read moreReview and source information
- Last reviewed
- 2026-07-28
- Reference
- Open reference ↗
Always compare this page with the current medicine label and advice from a qualified healthcare professional.
Most bought this month
- 1Dolo 650 TabletMicro Labs Ltd₹33.90
- 2Crocin Advance 500 TabletGlaxoSmithKline Pharmaceuticals Ltd₹22.25
- 3Calpol 650 TabletGlaxoSmithKline Pharmaceuticals Ltd₹30.50
- 4Cetzine TabletGlaxoSmithKline Pharmaceuticals Ltd₹25.70
- 5Mox 500 CapsuleSun Pharmaceutical Industries Ltd₹72.80
Ranked by how often readers opened a partner link in the last 30 days.
All medicines →