Aceclofenac 100mg + Paracetamol 325mg Tablet

• Pain and inflammation in osteoarthritis and rheumatoid arthritis
• Musculoskeletal, back and joint pain with swelling
• Dental and post-operative pain
• Soft-tissue injury and sprain pain
• Painful conditions accompanied by fever

Two complementary routes to relief: aceclofenac lowers prostaglandin production at the inflamed site, easing swelling and stiffness, while paracetamol acts centrally on pain signalling and on temperature control. Because the two act at different points, Aceclofenac 100mg + Paracetamol 325mg Tablet is used where inflammation, pain and fever are present together and a single agent has not given adequate relief.

One product instead of two: a fixed-dose tablet simplifies a short course, which is why this pairing is common in Indian prescribing for acute inflammatory pain.

The side-effect profile is dominated by the aceclofenac component: indigestion, stomach pain, nausea, diarrhoea and dizziness are the common effects. The paracetamol component adds few side effects at the usual dose.

• Stop the medicine and seek help for black or bloody stools, vomiting blood, severe stomach pain, swelling of the face, wheezing, or a marked fall in urine output.
• Because the tablet already contains paracetamol, adding a separate paracetamol, cold or flu remedy can push the daily paracetamol total into the range that damages the liver. This is the most common avoidable harm with combination painkillers and it does not apply to either ingredient taken alone.
• Taking any other NSAID alongside it adds no useful relief and sharply raises the risk of stomach bleeding.

• Aceclofenac 100mg + Paracetamol 325mg Tablet is taken only as prescribed, and usually as a short course. The ratio of the two ingredients is fixed, so the dose is changed by changing the prescription rather than by splitting tablets.
• It is taken with or immediately after food, which reduces stomach irritation from the anti-inflammatory component.
• The tablet is swallowed whole with water.
• The label of any other painkiller, cold or flu preparation should be checked before it is taken alongside this one — a large number of them contain paracetamol.

The two ingredients inhibit cyclo-oxygenase (COX) enzymes in different places. Aceclofenac acts mainly at the site of injury or inflammation, where reduced prostaglandin production lowers swelling, stiffness and pain. Paracetamol acts mainly within the brain and spinal cord, damping pain signalling and resetting the raised temperature set-point of a fever. That difference in site of action, rather than a simple additive effect, is why the pairing is used.

• Read the label of every other medicine in the house. Paracetamol is in a very large number of over-the-counter cold, flu and pain products, and doubling up is the main risk specific to this combination.
• Aceclofenac 100mg + Paracetamol 325mg Tablet is taken with food, not on an empty stomach.
• Alcohol compounds both risks here — stomach bleeding from the anti-inflammatory and liver injury from the paracetamol.
• A history of stomach ulcers, heart disease, high blood pressure, asthma, or kidney or liver problems should be discussed with the prescriber before Aceclofenac 100mg + Paracetamol 325mg Tablet is used.
• It is meant for short courses; pain that keeps returning needs a diagnosis rather than a longer supply.

• Any other paracetamol-containing product (cold and flu remedies, other combination painkillers): raises the total daily paracetamol dose toward the liver-damaging range.
• Other NSAIDs and aspirin: no added benefit, greatly increased risk of stomach ulcers and bleeding.
• Blood thinners (warfarin) and corticosteroids: higher bleeding risk from the anti-inflammatory component, and regular paracetamol can also affect INR.
• Blood pressure medicines (ACE inhibitors, diuretics): effect may be reduced and kidney risk increased.
• Lithium and methotrexate: levels may rise, increasing toxicity.
• Carbamazepine, phenytoin, rifampicin: increase the risk of liver injury from the paracetamol component.